16 Oct What is the ER Map Test (Endometrial Receptivity Map) and what it is used for?
The technological advances in the medical field constantly contribute to improve our health. Thanks to this, healthcare professionals can analyze in depth the different health problems of the society and the way to address them. In Assisted Reproduction, technology is a fundamental for the optimization of each stage in all treatments to increase the chances of success.
The Endometrial Receptivity Map (ER Map Test) is a study that allows to determine the state of receptivity of the endometrium during the implantation window (WOI). This test analyzes the gene expression of 48 genes involved in the receptivity levels of the endometrium. This way, the results will indicate the best moment of the endometrium to carry out the implantation of the embryo.
The objective of the ER Map Test is to determine the best moment of the endometrium to transfer the embryo in a cycle of assisted reproduction, in order to increase the chances of successful implantation and pregnancy.
What is the endometrial receptivity?
The endometrium is a membrane that lines the cavity of the uterus, preparing each month the womb to receive the implantation of the embryo. It is a tissue that undergoes changes throughout the menstrual cycle and reaches high levels of receptivity allowing the embryo to adhere to the wall of the uterus. Implantation is the beginning of pregnancy
Usually, the optimal moment of receptivity of the endometrium is around 19-21 of the menstrual cycle. It is the so-called implantation window (WOI).
ER Map Test: In what cases is it indicated to perform it?
Approximately 30% of the patients who undergo assisted reproduction treatment have a displaced implantation window. The ER Map Test can be very useful in patients who have suffered repeated implantation failures (2-3 times) after transfering good quality embryos. The study of endometrial receptivity is especially recommended in patients who experience multiple failed cycles.
However, it is a test that can also help women who have no apparent problems in the uterus or endometrium. It would be, therefore, a method of evaluating the receptivity of the endometrium.
Currently, the ER Map Test is the most reliable test available for the evaluation of endometrial receptivity.
How is the ER MAP performed?
An endometrial biopsy will be taken by your gynecologist in an Hormone Replacement Therapy (HRT) or Natural Cycle during the Window of Implantation. The biopsied material will be submitted to PGDLabs for analysis. Once the results are ready, they will be submitted to your doctor along with their interpretation. When an endometrium is classified as “receptive”, it means that the window of implantation matches the day on which the biopsy was taken. The embryo transfer will be scheduled to be performed on this day on the next cycle. If an endometrium is classified as “non-receptive”, it means that the WOI is displaced.
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