PGT-A, PGT-M and PGT-SR, new medical terms

PGT-A, PGT-M and PGT-SR, new medical terms

Working in the world of fertility implies learning ever-changing medical terms. We have witnessed the evolution of terms that we use daily at PGDLabs to describe the main techniques that we use in our reproductive genetic labs.

Recently, terms such as PGD (Preimplantation Genetic Diagnosis) and PGS (Preimplantation Genetic Screening), used to describe the detection of genetic disorders and chromosome anomalies in embryos, have been renewed as a recommendation to improve the coherence and communication between fertility professionals.

According to the latest updates, from now on, the right term to describe the types of genetic testing on embryos will be PGT (Preimplantation Genetic Testing). In order to adequately differentiate the various tests, PGT has been divided into three sub-types:

  • PGT-A. Formerly known as PGS, the Preimplantation Genetic Testing for Aneuploidies is employed to offer information regarding anomalies in the number of chromosomes (aneuploidies). It implies the study of embryos created through In-Vitro Fertilization (IVF) and its purpose is to help the team of specialists select the best embryo to be transferred, thereby increasing the chances of a successful pregnancy and reducing the rate of miscarriages.
  • PGT-M. Formerly known as PGD, the PGT for monogenic (single-gene) disorders will be known as PGT-M; a genetic test aimed at reducing the risk of conceiving a child with a specific hereditary disorder. PGT-M implies the analysis of embryos created through In-Vitro Fertilization (IVF) and the subsequent transfer of those embryos that have been diagnosed as unaffected by the disease.
  • PGT-SR. Designed for the study of structural chromosomal reorganizations (reciprocal translocations, inversions, etc.) that one or both members of the couple might bear. PGT-SR reduces the risk of becoming pregnant with a baby that has unbalanced structural anomalies. It works by analyzing embryos created through IVF, to then transfer the embryos that display normal chromosomes.

If you have questions about your infertility, reproductive medicine clinic professionals will assist you and provide you with the answers you need. At PGDLabs we specialize in genetics, determining which tests are recommended to increase the chances of success in your IVF cycle. If you have any questions, do not hesitate to contact us; we will gladly address any inquiries you may have. Looking forward to hearing from you!